An update on prevention and management of preterm birth


preterm birth, stress, inflammation, CRH, prevention, risk factors, tocolytics

M. Torricelli, M. De Bonis, C. Voltolini, N. Conti, L.R. Galeazzi, F. Vellucci, F.M. Severi, F. Petraglia

Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy.

Correspondence at:


Preterm birth is a pregnancy complication that is associated with neonatal adverse outcomes. It is considered an obstetric syndrome and several factors contribute to its pathogenesis, both of maternal and fetal origin. The knowledge of the pathogenetic mechanisms leading to preterm birth is very important in order to recognize women at risk and to perform the strategies for reducing the morbidity and mortality. Nowadays, the interventions to prevent preterm birth are represented by the administration of tocolytic and steroids drugs to mother and fetus, respectively. The development of new and safe drugs decreasing uterine contractility and infection will improve the prognosis of preterm birth.